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Asymmetry and/or unilateral GO can impose diagnostic challenges (13) and it is therefore important that awareness for asymmetric GO be raised. Indexed in Web of Science, PubMed, MEDLINE, and Scopus. It is important to note that published studies have used different definitions of asymmetry and/or unilateral GO and this might explain the big variation in reported epidemiology among published data. Given that the pathophysiological mechanisms causing unilateral or asymmetric GO appear to be similar to the well-described bilateral GO, treatment of asymmetric GO is generally the same with bilateral disease and is usually dependent on disease severity. Orbit (2009) 28:342–6. In the same study asymmetry was more prevalent in females and measurements from the right orbit were greater than the left (16). doi: 10.1046/j.1365-2265.1997.2331047.x, 28. Expression of lncRNA-HOTAIR in the serum of patients with lymph node metastasis of papillary thyroid carcinoma and its impact. doi: 10.4103/0301-4738.83612, 21. doi: 10.1007/s40618-020-01258-w, 13. Eye (2012) 26:1263–9. Background and Aims: The synthetic atypical cannabinoid Abn-CBD, a cannabidiol (CBD) derivative, has been recently shown to modulate the immune system in different organs, but its impact in obesity-related meta-inflammation remains unstudied. Prevalence of asymmetric exophthalmos in Graves orbitopathy. The present mini-review summarizes important information for both clinicians and researchers and also provides the impetus for further research. Quality of life in a german graves orbitopathy population. doi: 10.1371/journal.pone.0176064, 37. Autoimmune processes resulting in proliferation of orbital fibroblasts, increased adipogenesis, and extracellular matrix expansion are involved in its pathophysiology (5) and Thyroid Stimulating Hormone (TSH) Receptor Antibodies (TRAb) seem to be a key determinant. showed that a seven-fold higher risk for unilateral GO in hypothyroid or euthyroid subjects, compared with hyperthyroid GO (26). *Correspondence: Grigorios Panagiotou, gpanayio@gmail.com, Front. Normal measurement of orbital structures: implications for the assessment of Graves’ ophthalmopathy. Impact Factor. doi: 10.4158/EP.7.2.110, 41. Clinicians involved in the care of patients with GO need to be able to identify unilateral or asymmetric GO, as timely recognition of asymmetry may expedite referral to specialist services and facilitate further management. Shah SM, Joshi MR. An assessment of asymmetry in the normal craniofacial complex. Your IP: 37.59.215.78 Thyroid (2008) 18:541–4. There is no contraindication in regards to any treatment modality including antithyroid drugs, radioactive iodine, and/or total thyroidectomy for mild asymmetric and/or unilateral GO, while in moderate to severe cases radioiodine should be avoided, similarly to bilateral symmetric disease (42). Impact Factor 3.644 | CiteScore 3.4More on impact ›, Mechanisms and Novel Therapies in Graves’ Orbitopathy: Current Update Other differentials affecting the orbit including other orbital tumors or pseudotumors, carotid cavernous fistulae, and dermoid and/or epidermoid cysts need to be excluded, too. Br J Ophthalmol (2009) 93:1052–6. Loop enables you to stay up-to-date with the latest discoveries and news, connect with researchers and form new collaborations. doi: 10.1016/j.immuni.2020.01.005. It has been suggested that unilateral GO may progress to bilateral disease (11) and we have also found that asymmetry was associated with more severe and active GO (12). Ophthalmic Res (1989) 21:73–82. Shorter duration of symptoms (29) and thyroid status might be associated with asymmetry. Type 2 diabetes was induced in male Wistar rats by high fat diet (HFD, 60% of calories as fat) and STZ (20 mg/kg, intraperitoneal). Loop enables you to stay up-to-date with the latest discoveries and news, connect with researchers and form new collaborations. Tu X, Dong Y, Zhang H, Su Q. Corticosteroids for Graves’ Ophthalmopathy: Systematic Review and Meta-Analysis. Clin Endocrinol (1993) 38:367–72. However, some patients might exhibit asymmetric or unilateral symptoms, for yet unknown reasons. Open-access publisher of peer-reviewed scientific articles across the entire spectrum of academia. Insulin-like Growth Factor 1 Supports a Pulmonary Niche that Promotes Type 3 Innate Lymphoid Cell Development in Newborn Lungs. doi: 10.1016/j.ajo.2011.02.018, 11. Read the latest articles of Trends in Endocrinology & Metabolism at ScienceDirect.com, Elsevier’s leading platform of peer-reviewed scholarly literature Graves’ Orbitopathy (GO) is an autoimmune orbital disorder usually presenting as a sequala of autoimmune thyroid disease. Prummel MF, Bakker A, Wiersinga WM, Baldeschi L, Mourits MP, Kendall-Taylor P, et al. Eur J Internal Med (2008) 19:531–6. However, the exact mechanisms causing asymmetry remain elusive. Eur J Endocrinol (2006) 154:511–7. Int Ophthalmol (2020). doi: 10.1097/01.IOP.0000124675.80763.5A, 14. Scope. Citations (Scopus total) Articles published (total) ... Frontiers in Endocrinology. While most patients with GO present with bilateral disease, asymmetric or unilateral GO may affect a significant proportion of patients diagnosed with GO. The presence of GO is associated with increased psychological burden and, in severe cases may cause blindness. Endocrinol. International Scientific Journal & Country Ranking. The presence of GO is associated with increased psychological burden and, in severe cases may cause blindness. Facial asymmetry as an indicator of psychological, emotional, and physiological distress. 8. Ophthalmic Plast Reconstr Surg (2006) 22:319–24. Abraham-Nordling M, Bystrom K, Torring O, Lantz M, Berg G, Calissendorff J, et al. It was established in 2010 and is published by Frontiers Media, who was included on Jeffrey Beall's now-defunct list of "potential, possible, or probable predatory publishers". Radiological criteria for asymmetry, such a right-to-left ratio of more than 1.4 in extraocular muscle diameter, as obtained by CT measurements based on normative data, have also been proposed (24). With an Impact Factor of 3.675, Frontiers in Endocrinology is the 2nd most cited open-access journal in Endocrinology & Metabolism. Naik MN, Vasanthapuram VH. Wiersinga WM, Bleumink M, Saeed P, Baldeschi L, Prummel MF. Articles, Dipartimento di Endocrinologia, Fondazione IRCCS Ospedale Ca 'Granda Maggiore Policlinico, Italy. Moreover, disease severity is assessed similarly to bilateral disease, using clinically evaluated standardized tools, such as CAS (27) and Vision, Inflammation, Strabismus, Appearance (VISA) (28). doi: 10.1089/thy.2007.0302, 33. Furthermore, previous studies have shown associations of asymmetric/unilateral GO with disease activity and severity and it is crucial that large cohorts include patients of different clinical status. Eye (2006) 20:569–73. In specific, small studies have suggested that euthyroid and primarily hypothyroid patients develop more asymmetrical GO (34, 35), which tends to present more mildly. doi: 10.1111/j.1365-2265.2005.02352.x, 9. However, in a recently published retrospective hospital-based report from India, unilateral disease was much higher at 36% and significantly more common among silent presenters compared to the clinically active group (33). Shyu VB, Hsu CE, Chen CH, Chen CT. 3D-assisted quantitative assessment of orbital volume using an open-source software platform in a Taiwanese population. doi: 10.1136/bjo.2007.137265, 35. Front. Endocrinol., 17 December 2020 have speculated that asymmetric distribution of antigen or inflammatory processes may be the cause of asymmetrical expansion of orbital contents (13), though this was not explored in any studies so far. More specifically, in everyday clinical practice, unilateral disease needs to be differentiated from other pathologies affecting one eye. Unilateral GO is likewise variably defined as one or more features in one eye without any such manifestations in the other eye (20), proptosis >2 mm in one eye with normal examination of the other eye (25), or proptosis difference between eyes >4 mm, and/or if clinical signs and symptoms of GO found unilaterally (26). Am J Ophthalmol (2011) 152:483–490 e1. Psychosocial morbidity of Graves’ orbitopathy. Research network for academics to stay up-to-date with the latest scientific publications, events, jobs, video lectures, blogs and news. However, there are no prospective data evaluating whether early selenium supplementation in asymmetric GO cases may halt progression to bilateral symptoms. Thyroid (2017) 27:1475–80. BMC Ophthalmol (2013) 13:21. doi: 10.1186/1471-2415-13-21, 12. BioMed Res Int (2018) 2018:4845894. doi: 10.1155/2018/4845894, 45. Moura Neto A, Denardi FC, Delamain MT, Tambascia MA, Vassallo J, Caldato R, et al. Front. However, despite previous postulations the exact mechanisms remain elusive. Kashkouli MB, Nojomi M, Parvaresh MM, Sanjari MS, Modarres M, Noorani MM. Salvi M, Vannucchi G, Campi I, Rossi S, Bonara P, Sbrozzi F, et al. This year, 138 journals are listed in the category of Endocrinology & Metabolism in the 2016 edition of the Journal Citation Reports (JCR), of which 16 are open-access (OA).. Eckstein AK, Losch C, Glowacka D, Schott M, Mann K, Esser J, et al. Soroudi AE, Goldberg RA, McCann JD. In fact, TRAb titer together with smoking, duration of thyroid dysfunction and clinical activity score (CAS) at baseline are regarded as main risk factors for developing GO (6). doi: 10.1111/j.1440-1673.2007.01721.x, 25. Most cited open-access journals in Endocrinology & Metabolism . doi: 10.1159/000266782. Endocrinol. In the latter study, recruiting a large sample (n = 1,063) of normal Iranian subjects including children, a significantly greater proptosis in the right eye compared with the left via exophthalmometry was shown, though the difference was never greater than 2 mm (21). , Al-Shoumer KA these terms results from a prospective cross-sectional multicentre study important information for clinicians... Future, mechanistic studies are needed to explore the underlying pathological processes in asymmetric/unilateral GO therefore, more are! 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