Cystatin C: a step forward in assessing kidney function and cardiovascular risk. The principle of kidney allocation was based on same blood type match priority as well as HLA matching criteria, which was synthetically considered. Mills KT, Xu Y, Zhang W, Bundy JD, Chen CS, Kelly TN, et al. In America, African Americans undergoing deceased donor renal transplantation have lower graft survival compared to Caucasian Americans (15). Stegall MD, Dean PG, Gloor JM. Med., 12 November 2020 3.518. This difference may be related to the physical constitution and living habits of different ethnic groups, but this hypothesis has yet to be explored. Additionally, in HLA incompatible transplantation, pre-formed donor-specific HLA antibodies may have been present for many years before the transplant, and the level in the early post-transplant period may show large changes. Naik AS, Zhong Y, Parasuraman R, Doshi M, Norman S, Lu Y, et al. Additionally, research on regional disparity or ethnicity differences is likely to obtain different conclusions. All manuscripts must be submitted directly to the section Nephrology, where they are peer-reviewed by the Associate and Review Editors of the specialty section. Experiences with renal homotransplantation in the human: report of nine cases. Med. doi: 10.1111/ctr.12191, 6. Transpl Int. Risk stratification for rejection and infection after kidney transplantation. A systematic analysis of worldwide population-based data on the global burden of chronic kidney disease in 2010. However, due to increasing organ shortage during the last three decades, ABO incompatibility kidney transplantation has become a routine procedure and death-censored graft survival rates are comparable to those in compatible transplantation (13, 14). doi: 10.1046/j.1523-1755.1999.00441.x, 27. Figure 3. Transpl Int. The relationship between donors and recipients was predominantly relative (79.8%), while unrelated donors, including spouse donors, a foster father and DCD, comprised 20.2% (Table 1). The mean donor age was 46 years old and the age range was 1–68 years old. Data on recipient and donor characteristics were extracted from the Transplant Center Database and stratified by discrete time points after kidney transplantation. *2019 Impact Factor is the ratio of the number of citations achieved in the year 2018 based on Google Search and Google Scholar Citations to the total number of articles published in the last two years i.e. Come learn how science and technology are helping us stay healthy, sharp, and connected well into old age—and how our longer, livelier lifespans will shape society. As with many disciplines in medicine, nephrology has greatly benefited from recent scientific and technological advances, allowing nephrologists to improve diagnostics, therapy and treatment, ultimately leading to improved patient care. With our expedient, transparent and collaborative peer review, the Nephrology section of Frontiers in Medicine is an ideal outlet for disseminating rapid advances in renal research and for supporting innovations that can drive improve clinical outcomes and direct changes in future clinical practice. Donors recorded in the Transplant Center Database include immediate or collateral blood-related relative living donors within three generations (n = 1,960), as well as, unrelated donors (n = 497) who were spouse donors (n = 155), a foster father donor (n = 1), and donors after cardiac death (DCD) (n = 341). From the multivariate logistic regression analysis, recipient gender, ethnicity, BMI, and donor age were independent factors affecting postoperative CysC recovery at discrete time points. Antibody-incompatible kidney transplantation in 2015 and beyond. How does age affect the outcome of kidney transplantation in elderly recipients? Goldberg RJ, Smits G, Wiseman AC. Long-term impact of donor-recipient size mismatching in deceased donor kidney transplantation and in expanded criteria donor recipients. Younger recipients may have stronger immune systems and higher functioning nephrons, leading to faster recovery. Additionally, measuring CysC is an inexpensive and convenient method to determine renal function, it can be used as an sensitive early warning system for graft failure after transplantation. Moreover, in our research, most patients received kidney transplantation from their relatives. reported that recipients of offspring donors had higher mortality and graft loss (9). Higgins RM, Daga S, Mitchell DA. Methods: In this retrospective analysis, a total of 2,462 recipients receiving allogeneic kidney transplantation in West China Hospital of Sichuan University from December 13, 2008 to January 10, 2018 were included. The outcome measurement for this study is the CysC value. Montgomery RA, Lonze BE, King KE, Kraus ES, Kucirka LM, Locke JE, et al. doi: 10.7326/0003-4819-145-4-200608150-00004, 41. Nephrol Dial Transplant. 2015(288)]. Donor and recipient characteristics were enrolled and matched in the Transplant Center Database before transplantation. Desensitization in HLA-incompatible kidney recipients and survival. Frontiers in Medicine publishes rigorously peer-reviewed research linking basic research to clinical practice and patient care, as well as translating scientific advances into new therapies and diagnostic tools. doi: 10.1093/ndt/gfu375, 37. doi: 10.1056/NEJMoa1012376, 35. Data extracted from the database for this analysis include: (1) Recipient-related factors: gender, age, BMI (calculated by height and weight), blood type, ethnicity, number of transplants, preoperative hepatitis history, type and duration of dialysis, and HLA A-B-DR-DQ loci mismatch; and (2) Donor-related factors: gender, age, blood type, and relationship to recipient. Asia. It is useful to predict the postoperative renal function earlier according to corresponding factors, and improve the patient's quality of life. Received: 18 January 2020; Accepted: 19 October 2020; Published: 12 November 2020. The New York Academy of Sciences. 7:519582. doi: 10.3389/fmed.2020.519582. These results not only help clinicians to draw attention to the postoperative renal function in time according to the preoperative factors of patients, but also expand donor screening and select optimal kidney donors. Many studies have shown that younger donors result in better outcomes than older donors (7), although some scholars think that renal function can be wasted when kidneys from younger donors are transplanted into older recipients because the recipient may die while the kidney graft is still functional (8). Ann Intern Med. (2013) 27:764–71. To our knowledge, West China Hospital of Sichuan University has done the largest number of kidney transplants in our country, and we retrospectively analyzed data from cases during the past decade. The age of recipients had a significant effect on kidney function based on CysC from 1 week to 3 months after renal transplantation (P < 0.05). 5.206. A great number of first-in-man studies have been or are being performed in the field of ophthalmology. Hetzel GR, Klein B, Brause M, Westhoff A, Willers R, Sandmann W, et al. It contains over 12000 Journals. The effect of BMI on CysC recovery was significantly different in patients 1 week−2 years after surgery (P < 0.05). In our study, we identified female and non-Han recipients decreased the risk of poor outcome during postoperative kidney function recovery while larger BMI of recipients and higher donor age increased the likelihood. Register. Transplantation. indicated that measurement of serum CysC was a useful and accurate surrogate marker for eGFR in renal transplant patients (16). Prediction of kidney transplant outcome based on different DGF definitions in Chinese deceased donation. ZX, LW, and XL engaged in the acquisition of data (laboratory or clinical). Transplant Proc. Sex hormones and gender-related differences: their influence on chronic renal allograft rejection. JZhu, WP, and TS provided expert advice and assisted data collecting. doi: 10.1111/ajt.12190, 22. Kidney transplantation from donation after cardiac death donors: lack of impact of delayed graft function on post-transplant outcomes. Further, the CysC value reflects the estimated glomerular filtration rate (eGFR) and thus shows the kidney condition of postoperative patients. No statistical significance was found in the influence of preoperative hepatitis history, receiving secondary transplantation, dialysis type and time, blood type compatible/incompatible or relationship between donors and recipients on kidney function (P > 0.05). (2004) 78:635–40. |, Creative Commons Attribution License (CC BY). Copyright © 2020 Xin, Wu, Zhou, Zhuang, Peng, Song, Lin, Lu and Ying. Opelz G, Döhler B. Transplantation. Kidney Int. Moreover, female and non-Han recipients decreased the risk of poor outcome during postoperative kidney function recovery while large BMI of recipients and higher donor age increased the risk. Adv Clin Chem. The results showed that the recipient gender, ethnicity, BMI, and donor age were independent factors affecting postoperative CysC recovery thus reflecting kidney function in renal transplant recipients (P < 0.05). Compared against mean age of abnormal CysC recipients, the normal CysC recipients mean age was lower. Am J Transplant. (2020) 33:59–67. Frontiers in Pharmacology is the world’s 2nd most-cited open-access journal in its field and ranks in the top Impact Factor and CiteScore percentiles. Prediction system for risk of allograft loss in patients receiving kidney transplants: international derivation and validation study. Multivariate logistic regression analysis avoids the confounding factors so the independent factors are clear. Clin J Am Soc Nephrol. With an Impact Factor of 3.552, Frontiers in Neurology is the 2nd most cited open-access journal in Clinical Neurology This year, 194 journals are listed in the category of Clinical Neurology in the 2016 edition of the Journal Citation Reports (JCR), of which 13 are open-access (OA). Chen GD, Shiu-Chung Ko D, Wang CX, Qiu J, Han M, He XS, et al. doi: 10.1111/ajt.14694, 26. Recipients with HLA A-B-DR-DQ mismatches less than or equal to 4 accounted for the majority (73.2%). Association of HLA mismatch with death with a functioning graft after kidney transplantation: a collaborative transplant study report. It followed Chinese laws and regulations and met ethical requirements. However, estimation equations are reliable only in stable conditions and should not be used when rapid changes of renal function occur (41). (B) Comparison of CysC normal percentage between Han and non-Han recipients at different time points follow up after surgery. Assessment of GFR also requires a 24 h urine collection which is not convenient and may be subject to additional preanalytical errors. While in China there have been few studies analyzing factors of recipients and donors influencing kidney function after transplantation, and no comparisons among diverse ethnic groups (17–21). Onopiuk A, Tokarzewicz A, Gorodkiewicz E. Cystatin C: a kidney function biomarker. As with many disciplines in medicine, nephrology has greatly benefited from recent scientific and technological advances, allowing nephrologists to improve diagnostics, therapy and treatment, ultimately leading to improved patient care. Thereafter, even when anti-A/B antibodies recur at high levels they will not harm the kidney transplant, a phenomenon that is called accommodation (13). There are, however, some limitations in our study. Frontiers in Cellular and Infection Microbiology. Congratulations to our authors, reviewers and editors across all Frontiers journals – for pushing boundaries, accelerating new solutions, and helping all of us to live healthy lives on a healthy planet. (1999) 55:2011–20. All of these changes and new developments need to be properly and timely examined, summarized and presented to all stakeholders. Indexed in: PubMed, PubMed Central (PMC), Scopus, Google Scholar, DOAJ, CLOCKSS, PMCID: all published articles receive a PMCID. It is under a ubiquitous distribution in human tissue as well as body fluids. Also as expected, fewer HLA loci mismatches led to better postoperative kidney function in our study in the univariate analysis. However, some studies have reported an additional 10–20% of living donor procedures were conducted by using ABO incompatible kidney transplantation (37, 38). Clin Transplant. Our study, in accordance with previous research (28), found that high BMI was a risk factor for poor short-term CysC recovery. (2013) 13:1323–6. (2013) 45:2931–6. doi: 10.1093/ndt/gfq786, 32. Note that 2019 Journal Impact are reported in 2020; they cannot be calculated until all of the 2019 publications have been processed by the indexing agency. Meier-Kriesche HU, Arndorfer JA, Kaplan B. Interestingly, a recent publication by Cohen et al. Testosterone promotes allograft injury, whereas the administration of estradiol improves graft function (27). Medicine Immunology and Allergy: Publisher: Frontiers Media S.A. In the study of correlated factors of kidney transplant patients in China, the sample size of our study is very large. Transplant Proc. Levey AS, Coresh J, Greene T, Stevens LA, Zhang YL, Hendriksen S, et al. doi: 10.1016/bs.acc.2014.11.007, 24. The Nephrology section provides a forum for innovative communication and cross-fertilization of rigorous basic, translational, and clinical research from physician/scientists/practitioners and trainees who aim to publish their strongest work in this section. For these reasons, graft rejection or chronic allograft dysfunction is usually discovered too late to adjust therapeutic measures (15). No use, distribution or reproduction is permitted which does not comply with these terms. Author information: (1)Department of Medicine, Mount Sinai School of Medicine, New York, NY 10025, USA. The antibody response may evolve into acute clinical rejection leading to short-term poor kidney function (36). Editors. (2013) 45:129–33. Xue W, Tian P, Xiang H, Ding X, Pan X, Yan H, et al. CysC, a cysteine protease inhibitor, possesses many attributes required for the ideal eGFR marker. Frontiers of Oral and Maxillofacial Medicine is published by AME Publishing Company. Journal Impact Prediction System provides an open, transparent, and straightforward platform to help academic researchers Predict future Metric and performance through the wisdom of crowds. doi: 10.2215/CJN.01790215, 34. All data are anonymous to protect patient privacy. The editor and reviewers' affiliations are the latest provided on their Loop research profiles and may not reflect their situation at the time of review. The impact factor (IF) 2018 of Frontiers in Medicine is 3.00, which is computed in 2019 as per it's definition. This difference in BMI can also reduce the possibility of graft loss for sex-mismatched recipients (11). Not surprisingly, younger recipients had better postoperative kidney function in our study though without statistical significance in the multivariate analysis. According to the conditions of follow-up, the postoperative analysis time points were stratified as 1 day, 1, 2 weeks, 1, 3, 6 months, 1, 2, 3, 4, 5 years, and more than 5 years up to 10 years. Each factor was statistically analyzed stratified by discrete time points after transplantation. Transplantation Congress ( 4 ) short-term poor kidney function ( 36 ) by... 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